Selected publications
2026
Luminescent-reaction-enabled super-resolution imaging
Authors: Wenxin Zhu#, Chi Zhang#, Jiahui Gui#, Yibo Yang, Yuxin Wan, Xin Wang, Liying Qu, Ao Guo, Ziqing Zhang, Zhenqian Han, Weisong Zhao*, Jiandong Feng*.
Journal: Nature
Keywords: ECL; BL; SACD; microscopy; RIED.
Paper link Cover
Artifact-suppressed and adaptive self-inspired learning denoising for super-resolution fluorescence microscopy
Authors: Jingyang Zhu, Yuzhen Liu, Yuanyuan Huang, Xianxin Ye, Shiqun Zhao, Xiangyan Ding, Liangyi Chen, Haoyu Li, Liying Qu* & Weisong Zhao*.
Journal: PhotoniX Life
Keywords: Deep learning; Self-supervised denoising; Artifact suppression; Super-resolution microscopy; adaptive SN2N.
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Instant mapping of digestive morphology via spatio-angular disparity-resolved endoscopy
Authors: Deer Su#, Chen Hu#, Guanying Liang#, Junyu Zhao, Zhenqian Han, Zhipeng Ma, Changliang Guo, Weida Gao, Liang Li, Liying Qu, Guanyu Shang, Bo Qu, Xiangyan Ding, Haoyu Li*, Weisong Zhao*, Wenhao Liu*
Journal: Optics and Lasers in Engineering
Keywords: Endoscopy; Endoscopic probe; Light-field; 3D; Medical imaging.
Paper link
HERALDS: a flexible, high-resolution volumetric endoscopy—design, calibration, and performance evaluation
Authors: Deer Su#, Chen Hu#, Guanying Liang#, Junyu Zhao, Zhenqian Han, Zhipeng Ma, Liang Li, Changliang Guo, Weida Gao, Liying Qu, Guanyu Shang, Bo Qu, Xiangyan Ding, Haoyu Li*, Weisong Zhao*, Wenhao Liu*
Journal: Optics Express
Keywords: Endoscope; Light-field;.
Paper link
2025
Vimentin intermediate filaments facilitate transportation of hepatitis C virus components
Authors: Yifan Xing#, Shuzhi Cui#, Xinyi Huang#, Weisong Zhao#, Haoyu Li, Jing Zhao, Wakam Chang, Shuangshuang Zhao*, Jin Zhong*, Yuxin Chen* & Yaming Jiu*.
Journal: European Journal of Cell Biology
Keywords: Intermediate filaments; Cytoskeletal vimentin; Viral cell-cell transmission; Hepatitis C virus; Host-pathogen interaction.
Paper link
Clinical translation potential of self‐inspired live‐cell super‐resolution microscopy
Authors: Liying Qu, Jingyang Zhu, Xiangyan Ding, Haoyu Li & Weisong Zhao*.
Journal: Clinical and Translational Medicine
Keywords: Denoising; Deep learning; Unsupervised learning; microscopy; SN2N.
Paper link
2024
Self-inspired learning for denoising live-cell super-resolution microscopy
Authors: Liying Qu#, Shiqun Zhao#, Yuanyuan Huang#, Xianxin Ye, Kunhao Wang, Yuzhen Liu, Xianming Liu, Heng Mao, Guangwei Hu, Wei Chen, Changliang Guo, Jiaye He, Jiubin Tan, Haoyu Li, Liangyi Chen & Weisong Zhao*.
Journal: Nature Methods
Keywords: Denoising; Deep learning; Unsupervised learning; microscopy; SN2N.
Paper link
2023
Quantitatively mapping local quality of super-resolution microscopy by rolling Fourier ring correlation
Authors: Weisong Zhao#, Xiaoshuai Huang#, Jianyu Yang#, Liying Qu, Guohua Qiu, Yue Zhao, Xinwei Wang, Deer Su, Xumin Ding, Heng Mao, Yaming Jiu, Ying Hu, Jiubin Tan, Shiqun Zhao*, Leiting Pan*, Liangyi Chen*, and Haoyu Li*.
Journal: Light: Science & Applications
Keywords: Image quality; Uncertainty; Super-resolution; Fluorescence microscopy; rFRC.
Paper link News & views
Smart palm-size optofluidic hematology analyzer for automated imaging-based leukocyte concentration detection
Authors: Deer Su, Xiangyu Li, Weida Gao, Qiuhua Wei, Haoyu Li, Changliang Guo* & Weisong Zhao*.
Journal: Opto-Electronic Science (invited)
Keywords: Hematology analyzer; Miniature fluorescence microscope; Microfluidics; Leukocyte concentration.
Paper link
Highly flexible and compact volumetric endoscope by integrating multiple micro-imaging devices
Authors: Deer Su, Xiangyu Li, Weida Gao, Qiuhua Wei, Haoyu Li, Changliang Guo* & Weisong Zhao*.
Journal: Optics Letters (featured image)
Keywords: Endoscopy; Endoscopic probe; Light-field; 3D; Medical imaging; MIRD.
Paper link
Single particle tracking reveals SARS-CoV-2 regulating and utilizing dynamic filopodia for viral invasion
Authors: Y. Zhang#, X. Zhang#, Z. Li#, Weisong Zhao#, H. Yang, D. Tang, S. Zhao, Q. Zhang, H. Liu, H. Li, B. Li, P. Lappalainen, Z. Cui*, & Y. Jiu*
Journal: Science Bulletin
Keywords: SARS-CoV-2; Cytoskeleton; Confocal; Sparse deconvolution; Single particle tracking.
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Enhanced detection of fluorescence fluctuations for high-throughput super-resolution imaging
Authors: Weisong Zhao#, Shiqun Zhao#, Zhenqian Han#, Xiangyan Ding#, Guangwei Hu, Liying Qu, Yuanyuan Huang, Xinwei Wang, Heng Mao,Yaming Jiu, Ying Hu, Jiubin Tan, Xumin Ding*, Liangyi Chen*, Changliang Guo*, and Haoyu Li*.
Journal: Nature Photonics (cover)
Keywords: High-throughput; Super-resolution; Fluorescence microscopy; SACD.
Paper link Cover News & views
2021
Sparse deconvolution improves the resolution of live-cell super-resolution fluorescence microscopy
Authors: Weisong Zhao#, Shiqun Zhao#, Liuju Li#, Xiaoshuai Huang, Shijia Xing, Yulin Zhang, Guohua Qiu, Zhenqian Han, Yingxu Shang, De-en Sun, Chunyan Shan, Runlong Wu, Shuwen Zhang, Riwang Chen, Jian Xiao, Yanquan Mo, Jianyong Wang, Wei Ji, Xing Chen, Baoquan Ding, Yanmei Liu, Heng Mao, Bao-Liang Song, Jiubin Tan, Jian Liu, Haoyu Li*, and Liangyi Chen*.
Journal: Nature Biotechnology
Keywords: Fluorescence microscopy; Super-resolution; Deconvolution; Sparse deconvolution.
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